N-Acetyl-para-aminophenol as an Analgesic
نویسندگان
چکیده
منابع مشابه
N-acetylpara-aminophenol as an analgesic; a controlled clinical trial using the method of sequential analysis.
veretum (" omnopon ") 3 gr. (22 mg.), six-hourly. Adequate post-operative analgesia to facilitate early leg and breathing exercises has been found to be especially valuable, and rigorous adherence to this regimen has lowered the incidence of fatal pulmonary embolism to one in the last 1,000 major gynaecological operations performed by one of us (E. C.). During this trial no obvious respiratory ...
متن کاملEffect of Paracetamol (n-acetyl-p-aminophenol) on Gastrointestinal Bleeding.
There is now ample evidence that the oral administration of aspirin leads to an increase in faecal blood loss in the majority of normal people. Some investigators (Lange, 1957; Alvarez and Summerskill 1958; Stubbe, Pietersen, and Van Heulen, 1962) have used chemical means of testing for occult blood in faeces, and others (Matsumoto and Grossman, 1959; Watson and Pierson, 1960; Holt, 1960; Scott...
متن کاملDetermination of n-acetyl-p-aminophenol in plasma.
Two methods for the determination of N-acetyl-p-aminophenol (APAP) in plasma that differ in principle from the diazotization procedure of Brodie and Axelrod (1) are described. One method based on the differential absorption peak of APAP at 266 m, which corresponds to the isosbestic point of common drugs such as acetylsalicylic and salicylic acids, is simple and most specific for APAP. The other...
متن کاملMetabolism of para-aminophenol by rat hepatocytes.
Autoxidation of para-aminophenol (PAP) has been proposed to account for the selective nephrotoxicity of this compound. However, other studies suggest that hepatic metabolites of PAP rather than the parent compound may be responsible for renal damage. These studies were designed to investigate PAP metabolism in isolated hepatocytes. We synthesized several proposed metabolites for analysis by HPL...
متن کاملGas-chromatographic method for acetaminophen (N-acetyl-p-aminophenol) based on sequential alkylation.
A gas-chromatographic procedure for acetaminophen is described in which the drug is chromatographed as the O-heptyl-N-methyl derivative. This derivative is prepared by a sequential alkylation procedure in which the phenolic hydroxyl group of the parent compound is alkylated off-column with heptyl iodide and the amide group is derivatized on-column by reaction with trimethylanilinium hydroxide. ...
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ژورنال
عنوان ژورنال: BMJ
سال: 1956
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5001.1096